Selective Polymer Microparticles for Delivering Viable Bacteria/Microorganisms
Prof. Peter Lieberzeit, University of Vienna, Dept. of Physical Chemistry; Prof. Alexander Bismarck, University of Vienna, Dept. of Materials Chemistry and Research; Julia Perko, University of Vienna, Dept. of Physical Chemistry; Martin Werner, University of Vienna, Dept. of Physical Chemistry
University of Vienna
Fecal microbiota transplant (FMT) is a recommended treatment strategy for infectious diseases and irritable bowel syndrome. Current methods for transplanting the stool of a healthy individual to a patient involves nasojejunal tubes, colonoscopy or an orally administered encapsulated product, which is unappealing for patients. Therefore, patience acceptance of FMT needs to be improved. This issue is addressed by the presented technology that is supplying patients with living microorganism using “clean” pharmaceutical produced polymer microparticles for delivery of bacteria.
Bacteria imprinted polymer microspheres are produced via Pickering emulsion under retention of bacteria viability. Any hospital working with digestion-related diseases could take advantage of this technology.
Bacteria loaded microparticles can be used in following conditions: Irritable bowel syndrome which affects up to 50 % of patients visiting a gastroenterologist. Prebiotics supplementation is commonly recommended upon antibiotic treatment. Further infectious diseases, such as potentially life-threatening infection with Clostridium difficile, can be targeted.
European patent application filed 06/06/2019
(EP3747987A published 09/12/2020), PCT filed 05/06/2020
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