Cookie Preference

This website uses cookies to improve user experience. Please select an option.  Privacy Policy

No cookies except for those necessary for technical reasons are set.

Startups 2021

Rising Startup

PROSION GmbH

Dr Slim Chiha, Mutlu Yönel, Dr Wolfgang Söhngen

Innovation & Business Idea

PROSION developed a first-in-class approach to address so far undruggable targets that are linked with various hard-to-treat diseases through a disruptive platform of chemical building blocks called ProMs. ProMs can be combined to small molecule drugs for a very abundant class of "undruggables”, namely PRM-binding targets. These targets are known to play key-roles in a multitude of pathologies, e.g. cancer, Alzheimer’s, cardiovascular diseases, etc.

The potential of the ProM-platform has already been validated in vivo in a first POC targeting Ena/VASP, a particularly difficult oncological PRM-binding target.

As a clear "first mover" in this field, PROSION intends to exploit the value and potential of the ProM-platform through the systematic development of ProM-based drug leads in collaboration with key partners.


Customers / Target Market

PROSION’s business model addresses a trend within the pharmaceutical industry, with established companies heavily screening the market for external innovation. Based on the promising results for Ena/VASP as a proof-of-concept and the know-how of more than a decade of research, PROSION aims to exploit the value and potential of the ProM-platform by using a hybrid model:

Firstly, seeking an alignment with bio/pharmaceutical companies as cooperation partners, either early-on (during the preclinical development) or somewhat later (during the clinical development). Secondly, taking drug development projects from the preclinical phase through a first-in-human study and eventually through the clinical development by itself. A case-by-case decision will be taken, depending on which of these two options fits best. The primary goal will be to systematically develop a strong pipeline of ProM-based drug candidates.


Competitors

PROSION will be the first company worldwide to feature a technology to develop small molecule inhibitors of PRM-mediated interactions. So far, no direct competitors on the market have successfully inhibited PRM-recognizing targets with low molecular weight inhibitors.


Intellectual Property Status

5 granted patents, mostly internationalized - US & JP. Secured IP-transfer agreement with the spin-off insitutions.


Development Status & Future Steps

Most recently conducted experiments in breast and pancreatic cancer mouse models indicate very promising results regarding efficacy and toxicity. Next major developments include (1) a second rodent experiment and a tox study in mini-pigs – (2) and the closing of cooperation with a pharma partner.


Exit Strategy

IPO or acquisition by a strategic partner – for both these options, having a strong pipeline will be of key importance. PROSION’s cooperation-focused business model naturally paves the way for such an acquisition.


Team Description

PROSION's founding team brings together a wide range of skills - including experienced medicinal chemists, entrepreneurs and scientific experts from academia. Dr. Chiha acts as a CEO and operates scientific development, while Mr. Yönel manages the financial aspects. Prof. Dr. Schmalz and Dr. Kühne act as advisors to all scientific subjects. Dr. Söhngen (former CEO @ PAION AG) recently joined and takes on the role of COO a.i., bringing a wide experience in the pharma industry. The management team is supported by a highly-skilled technical team of devoted researchers, which have been with the project since its inception. PROSION is also backed by Prof. ten Dijke, a specialist in cancer-cell signaling and Prof. Dr. Metternich, a Senior Research Executive with 30 years of pharma leadership experience.


Financing Need

-


Searching for

Commercial Partner, Funding, Collaboration